![]() They may be lymphocytic cells or come from other lines of blood cells. The cancerous cells can be found circulating in the bloodstream. Leukemia starts in the cells that produce blood cells in the bone marrow. Some key differences between lymphoma and leukemia are the location in which the cancer starts and where the cancer cells are found. It can be aggressive but is curable.īoth leukemia and lymphoma are blood cancers. Anaplastic large-cell lymphoma: This lymphoma is more likely to be seen in children and younger adults.It may be more likely in those who are intolerant to gluten. Enteropathy-associated intestinal T-cell lymphoma: Most common in Europeans, this lymphoma starts in the intestines.It usually starts in the sinuses or nasal passages. Extra-nodal natural killer/T-cell lymphoma, nasal type: This is an aggressive lymphoma most commonly found in Asian and Hispanic populations and is very aggressive.It has different types that can be aggressive or indolent. Adult T-cell lymphoma/leukemia: This lymphoma is caused by a virus and is most common in areas of the world such as Japan, Africa, and the Caribbean.Initially, they may be indolent lymphomas but can become aggressive and move to internal organs. Cutaneous T cell lymphomas ( mycosis fungoides, Sezary syndrome): These T-cell lymphomas start in the skin, and can have a rash-like appearance that spreads across the body.It is an aggressive cancer but curable if caught early. It starts in the thymus gland, a lymphatic organ in the chest. ![]() T-lymphoblastic lymphoma/leukemia: This type most commonly occurs in teens or young adults.This topic addresses the diagnosis and treatment of MF and SS. MF frequently behaves as an indolent lymphoma with good prognosis for early-stage disease, while SS is considered a more aggressive form of the disease, associated with shortened survival. Clinical end points and response criteria in mycosis fungoides and Sézary syndrome: a consensus statement of the International Society for Cutaneous Lymphomas, the United States Cutaneous Lymphoma Consortium, and the Cutaneous Lymphoma Task Force of the European Organisation for Research and Treatment of Cancer. Mycosis fungoides (MF) and its leukemic variant, Sézary syndrome (SS), are the most common subtypes. DefinitionĬutaneous T-cell lymphomas (CTCL) make up a heterogeneous group of uncommon disorders characterized by clonal accumulation of T lymphocytes primarily or exclusively in the skin. Treatment may induce remission, but patients are expected to relapse after a variable interval as complete cure is rare. Patients diagnosed with early-stage disease have a higher rate of survival. Clinical trials may be considered in early or advanced disease. The choice of skin-directed therapy or systemic treatment is dependent on both doctor and patient preference no one treatment option has been shown to be superior to another. If skin disease progresses, or the patient presents with advanced disease, systemic therapies are often necessary (chemotherapy, biologic or immunologic therapy, photopheresis). Cutaneous T-cell lymphoma diagnosis is based on a combination of clinical, histologic, immunophenotypic, and genetic data, and usually requires specialist expertise.Įstablishing a diagnosis can be challenging, as the condition can take many different forms in the skin: flat patches, raised plaques, large tumors, and/or marked erythroderma (intense and widespread reddening of the skin).Įarly-stage disease is usually managed with skin-directed therapy (topical medications, phototherapy, and localized radiation therapy).
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